Kolaja, Kyle: search on Z-Library

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1

Nonclinical safety assessment of epigenetic modulatory drugs: Current status and industry perspective

Reynolds, Vincent L., Butler, Paul, Abernathy, Matthew M., Aschenbrenner, Laura, Best, Derek D., Blank, Jim, Crosby, Meredith, Custer, Laura, Escobar, Patricia A., Kolaja, Kyle, Moggs, Jonathan, Shuey

Journal:

Regulatory Toxicology and Pharmacology

Year:

2020

File:

PDF, 487 KB

2020

2

Cardiotoxicity of kinase inhibitors: the prediction and translation of preclinical models to clinical outcomes

Force, Thomas, Kolaja, Kyle L.

Journal:

Nature Reviews Drug Discovery

Year:

2011

Language:

english

File:

PDF, 468 KB

english, 2011

3

Defining pharmacological and toxicological actions of cardiac glycosides by MEA in human iPS-derived cardiomyocytes

Liang Guo, Rory Abrams, Blake Anson, Kyle Kolaja

Journal:

Journal of Pharmacological and Toxicological Methods

Year:

2011

Language:

english

File:

PDF, 70 KB

english, 2011

4

Stem cell derived tissues and microphysiological systems: A paradigm shifting moment

Journal:

The Veterinary Journal

Year:

2013

Language:

english

File:

PDF, 164 KB

english, 2013

5

The Roche experience with the EST assay: Development of a new algorithm and hanging drop culture device for improved prediction and full automation

Claudia McGinnis, Nicole Schaefer, Tom Kissling, Thomas Zumstein, Christof Fattinger, Kyle Kolaja, Thomas Singer, Thomas Weiser, Nicole Clemann

Journal:

Reproductive Toxicology

Year:

2012

Language:

english

File:

PDF, 36 KB

english, 2012

6

Vitamin E Modulation of Hepatic Focal Lesion Growth in Mice1

Kyle L. Kolaja, James E. Klaunig

Journal:

Toxicology and Applied Pharmacology

Year:

1997

Language:

english

File:

PDF, 150 KB

english, 1997

7

The role of early in vivo toxicity testing in drug discovery toxicology

Fielden, Mark R, Kolaja, Kyle L

Journal:

Expert Opinion on Drug Safety

Year:

2008

Language:

english

File:

PDF, 124 KB

english, 2008

8

Toxicogenomics: an opportunity to optimise drug development and safety evaluation

Kolaja, Kyle L, Kramer, Jeffrey A

Journal:

Expert Opinion on Drug Safety

Year:

2002

Language:

english

File:

PDF, 242 KB

english, 2002

9

NSAID-Induced Acute Phase Response is Due to Increased Intestinal Permeability and Characterized by Early and Consistent Alterations in Hepatic Gene Expression

Tugendreich, Stuart, Pearson, Cecelia, Sagartz, John, Jarnagin, Kurt, Kolaja, Kyle

Journal:

Toxicologic Pathology

Year:

2006

Language:

english

File:

PDF, 1.12 MB

english, 2006

10

VITAMIN E MODULATION OF DIELDRIN-INDUCED HEPATIC FOCAL LESION GROWTH IN MICE

Kyle L. Kolaja Yong Xu Earl F. Walb,

Journal:

Journal of Toxicology and Environmental Health

Year:

1998

Language:

english

File:

PDF, 193 KB

english, 1998

11

Dose-Response Examination of UDP-Glucuronosyltransferase Inducers and Their Ability to Increase both TGF- β Expression and Thyroid Follicular Cell Apoptosis

Kolaja, Kyle L., Klaassen, Curtis D.

Journal:

Toxicological Sciences

Year:

1998

Language:

english

File:

PDF, 4.58 MB

english, 1998

12

GADD45α induction in the greenscreen HC indicator assay does not occur independently of cytotoxicity

Andrew J. Olaharski, Silvio Albertini, Lutz Mueller, Andreas Zeller, Melanie Struwe, Elmar Gocke, Kyle Kolaja

Journal:

Environmental and Molecular Mutagenesis

Year:

2011

Language:

english

File:

PDF, 133 KB

english, 2011

13

Drug discovery: Computer model predicts side effects

Journal:

Year:

2012

Language:

english

File:

PDF, 344 KB

english, 2012

14

Mechanism of subendocardial cell proliferation in the rat and relevance for understanding drug-induced valvular heart disease in humans

Mark R. Fielden, Mary Hassani, Hirdesh Uppal, Patricia Day-Lollini, Donald Button, Renee S. Martin, Rosario Garrido, Xingrong Liu, Kyle L. Kolaja

Journal:

Experimental and Toxicologic Pathology

Year:

2010

Language:

english

File:

PDF, 710 KB

english, 2010

15

Response to “Genotoxic carcinogen or not genotoxic carcinogen? That is the question. Additional analysis of data from Olaharski et al.”

Andrew Olaharski, Kyle Kolaja, Silvio Albertini, Hirdesh Uppal, Henry Lin, Stephan Kirchner, Stefan Platz

Journal:

Mutation Research/Genetic Toxicology and Environmental Mutagenesis

Year:

2009

Language:

english

File:

PDF, 78 KB

english, 2009

16

Evaluation of the GreenScreen GADD45α-GFP indicator assay with non-proprietary and proprietary compounds

Andrew Olaharski, Silvio Albertini, Stephan Kirchner, Stefan Platz, Hirdesh Uppal, Henry Lin, Kyle Kolaja

Journal:

Mutation Research/Genetic Toxicology and Environmental Mutagenesis

Year:

2009

Language:

english

File:

PDF, 598 KB

english, 2009

17

Thalidomide Inhibits Human iPSC Mesendoderm Differentiation by Modulating CRBN-dependent Degradation of SALL4

Belair, David G., Lu, Gang, Waller, Laura E., Gustin, Jason A., Collins, Nathaniel D., Kolaja, Kyle L.

Journal:

Scientific Reports

Year:

2020

Language:

english

File:

PDF, 5.09 MB

english, 2020

18

Human ileal organoid model recapitulates clinical incidence of diarrhea associated with small molecule drugs

Belair, David G., Visconti, Richard J., Hong, Miyoun, Marella, Mathieu, Peters, Matthew F., Scott, Clay W., Kolaja, Kyle L.

Journal:

Toxicology in Vitro

Year:

2020

File:

PDF, 11.18 MB

2020

19

Determination of the Human Cardiomyocyte mRNA and miRNA Differentiation Network by Fine-Scale Profiling

Babiarz, Joshua E., Ravon, Morgane, Sridhar, Sriram, Ravindran, Palanikumar, Swanson, Brad, Bitter, Hans, Weiser, Thomas, Chiao, Eric, Certa, Ulrich, Kolaja, Kyle L.

Journal:

Stem Cells and Development

Year:

2012

Language:

english

File:

PDF, 657 KB

english, 2012

20

Dose–Response Examination of UDP-Glucuronosyltransferase Inducers and Their Ability to Increase both TGF-β Expression and Thyroid Follicular Cell Apoptosis

Kyle L. Kolaja, Curtis D. Klaassen

Journal:

Toxicological Sciences

Year:

1998

Language:

english

File:

PDF, 741 KB

english, 1998

21

308 Drugmatrix™ provides predictive chemogenomics solutions for safety assessment in drug discovery and development

Pauline Gee, Richard Mitchell, Leslie Browne, Kyle Kolaja, Kurt Jarnagin, George Natsoulis, Alan Roter

Journal:

Toxicology Letters

Year:

2003

Language:

english

File:

PDF, 63 KB

english, 2003

22

Subchronic Effects of Dieldrin and Phenobarbital on Hepatic DNA Synthesis in Mice and Rats

Kyle L. Kolaja, Donald E. Stevenson, Jason T. Johnson, Earl F. Walborg, Jr., James E. Klaunig

Journal:

Fundamental and Applied Toxicology

Year:

1996

Language:

english

File:

PDF, 208 KB

english, 1996

23

The UDP-glucuronyltransferase inducers, phenobarbital and pregnenolone-16α-carbonitrile, enhance thyroid-follicular cell apoptosis: association with TGF-β1 expression

Kyle L. Kolaja, Alan M. Hood, Curtis D. Klaassen

Journal:

Toxicology Letters

Year:

1999

Language:

english

File:

PDF, 346 KB

english, 1999

24

Differential Display in Rat Livers Treated for 13 Weeks with Phenobarbital Implicates a Role for Metabolic and Oxidative Stress in Nongenotoxic Carcinogenicity

Elrick, Mollisa, Kramer, Jeffrey, Alden, Carl, Blomme, Eric, Bunch, Roderick, Cabonce, Marc, Curtiss, Sandra, Kier, Larry, Kolaja, Kyle, Rodi, Charles, Morris, Dale

Journal:

Toxicologic Pathology

Year:

2005

Language:

english

File:

PDF, 187 KB

english, 2005

25

Inhibition of gap-junctional-intercellular communication in thyroid-follicular cells by propylthiouracil and low iodine diet

Kyle L Kolaja, Jay S Petrick, Curtis D Klaassen

Journal:

Year:

2000

Language:

english

File:

PDF, 1.20 MB

english, 2000

26

HPLC–MS/MS methods for the quantitative analysis of 5-oxoproline (pyroglutamate) in rat plasma and hepatic cell line culture medium

Suzanne Geenen, Cristina Guallar-Hoyas, Filippos Michopoulos, J. Gerry Kenna, Kyle L. Kolaja, Hans. V. Westerhoff, Paul Thomas, Ian D. Wilson

Journal:

Journal of Pharmaceutical and Biomedical Analysis

Year:

2011

Language:

english

File:

PDF, 764 KB

english, 2011

27

Comparative Effects of Dieldrin on Hepatic Ploidy, Cell Proliferation, and Apoptosis in Rodent Liver

Kamendulis, Lisa M., Kolaja, Kyle L., Stevenson, Donald E., Jr, Earl F. Walborg, Klaunig, James E.

Journal:

Journal of Toxicology and Environmental Health

Year:

2001

Language:

english

File:

PDF, 226 KB

english, 2001

28

Acute Molecular Markers of Rodent Hepatic Carcinogenesis Identified by Transcription Profiling

Kramer, Jeffrey A., Curtiss, Sandra W., Kolaja, Kyle L., Alden, Carl L., Blomme, Eric A. G., Curtiss, William C., Davila, Julio C., Jackson, Carmen J., Bunch, Roderick T.

Journal:

Chemical Research in Toxicology

Year:

2004

Language:

english

File:

PDF, 404 KB

english, 2004

29

HPLC–MS/MS methods for the quantitative analysis of ophthalmic acid in rodent plasma and hepatic cell line culture medium

Suzanne Geenen, Filippos Michopoulos, J. Gerry Kenna, Kyle L. Kolaja, Hans. V. Westerhoff, Ian Wilson

Journal:

Journal of Pharmaceutical and Biomedical Analysis

Year:

2011

Language:

english

File:

PDF, 540 KB

english, 2011

30

Inhibition of gap-junctional-intercellular communication in intact rat liver by nongenotoxic hepatocarcinogens

Kyle L Kolaja, Dustin T Engelken, Curtis D Klaassen

Journal:

Year:

2000

Language:

english

File:

PDF, 195 KB

english, 2000

31

Human Stem Cell-Derived Cardiomyocytes in Cellular Impedance Assays: Bringing Cardiotoxicity Screening to the Front Line

Peters, Matthew F., Lamore, Sarah D., Guo, Liang, Scott, Clay W, Kolaja, Kyle L.

Journal:

Cardiovascular Toxicology

Year:

2015

Language:

english

File:

PDF, 1.23 MB

english, 2015

32

CANCER BIOLOGY: Reversibility of promoter induced hepatic focal lesion growth in mice

Kolaja, Kyle L., Stevenson, Donald E., Walborg, Earl F., Klaunig, James E.

Journal:

Year:

1996

Language:

english

File:

PDF, 2.10 MB

english, 1996

33

Supplement 1 || The Role of Oxidative Stress in Chemical Carcinogenesis

James E. Klaunig, Yong Xu, Jason S. Isenberg, Stephen Bachowski, Kyle L. Kolaja, Jiazhong Jiang, Donald E. Stevenson and Earl F. Walborg, Jr.

Journal:

Environmental Health Perspectives

Year:

1998

Language:

english

File:

PDF, 636 KB

english, 1998

34

A Gene Expression Signature that Predicts the Future Onset of Drug-Induced Renal Tubular Toxicity

Fielden, Mark, Eynon, Barrett, Natsoulis, Georges, Jarnagin, Kurt, Banas, Deborah, Kolaja, Kyle

Journal:

Toxicologic Pathology

Year:

2005

Language:

english

File:

PDF, 1.00 MB

english, 2005

35

Cancer Genetics and the Cardiotoxicity of the Therapeutics

Lal, Hind, Kolaja, Kyle L., Force, Thomas

Journal:

Journal of the American College of Cardiology

Year:

2013

Language:

english

File:

PDF, 876 KB

english, 2013

36

The Electrophysiological Effects of Cardiac Glycosides in Human iPSC-derived Cardiomyocytes and in Guinea Pig Isolated Hearts

Guo, Liang, Qian, Jian-Yong, Abrams, Rory, Tang, Hai-Ming, Weiser, Thomas, Sanders, Martin J., Kolaja, Kyle L.

Journal:

Cellular Physiology and Biochemistry

Year:

2011

Language:

english

File:

PDF, 609 KB

english, 2011

37

In vitro to in vivo concordance of a high throughput assay of bone marrow toxicity across a diverse set of drug candidates

Andrew J. Olaharski, Hirdesh Uppal, Matthew Cooper, Stefan Platz, Tanja S. Zabka, Kyle L. Kolaja

Journal:

Toxicology Letters

Year:

2009

Language:

english

File:

PDF, 219 KB

english, 2009

38

CARDIOVASCULAR TOXICTY INDUCED BY KINASE INHIBITORS: Mechanisms and Preclinical approaches

Lamore, Sarah, Kohnken, Rebecca A., Peters, Matthew F., Kolaja, Kyle L.

Journal:

Chemical Research in Toxicology

Year:

2019

File:

PDF, 549 KB

2019

39

Validation of a urethane-anesthetized guinea pig model for QT and hemodynamics assessment

Hong Wang, Rui Zhang, Justin Ly, Hai Ming Tang, Stefan Platz, Kyle Kolaja, Dinah Misner

Journal:

Journal of Pharmacological and Toxicological Methods

Year:

2009

Language:

english

File:

PDF, 55 KB

english, 2009

40

The effects of jaspamide on human cardiomyocyte function and cardiac ion channel activity

Schweikart, Karen, Guo, Liang, Shuler, Zachary, Abrams, Rory, Chiao, Eric T., Kolaja, Kyle L., Davis, Myrtle

Journal:

Toxicology in Vitro

Year:

2013

Language:

english

File:

PDF, 1.29 MB

english, 2013

41

Realizing the potential of IPS cells and derived tissues—from banking to improved safety assessment to microphysiological systems

Journal:

Toxicology Letters

Year:

2013

Language:

english

File:

PDF, 59 KB

english, 2013

42

4-Hydroxynonenal and Malondialdehyde Hepatic Protein Adducts in Rats Treated with Carbon Tetrachloride: Immunochemical Detection and Lobular Localization

Dylan P. Hartley, Kyle L. Kolaja, John Reichard, Dennis R. Petersen

Journal:

Toxicology and Applied Pharmacology

Year:

1999

Language:

english

File:

PDF, 731 KB

english, 1999

43

Testicular gene expression profiling following 2-methoxyethanol and 2-ethoxyethanol exposure in male rats reveals abnormal expression of the actin binding protein cortactin in degenerating spermatocytes

Elizabeth G. Tonkin, Matthew Cooper, Lance O. Lollini, Patricia A. Day-Lollini, John Allard, Kyle L. Kolaja, Stefan J. Platz, Sushmita M. Chanda

Journal:

Toxicology Letters

Year:

2009

Language:

english

File:

PDF, 1.11 MB

english, 2009

44

Identification of a Kinase Profile that Predicts Chromosome Damage Induced by Small Molecule Kinase Inhibitors

Olaharski, Andrew J., Gonzaludo, Nina, Bitter, Hans, Goldstein, David, Kirchner, Stephan, Uppal, Hirdesh, Kolaja, Kyle, Briggs, James M.

Journal:

PLoS Computational Biology

Year:

2009

Language:

english

File:

PDF, 500 KB

english, 2009

45

Developing in vitro assays to transform gastrointestinal safety assessment: potential for microphysiological systems

Peters, Matthew F., Choy, Allison L., Pin, Carmen, Leishman, Derek J., Moisan, Annie, Ewart, Lorna, Guzzie-Peck, Peggy J., Sura, Radhakrishna, Keller, Douglas A., Scott, Clay W, Kolaja, Kyle L.

Journal:

Year:

2020

File:

PDF, 355 KB

2020

46

Epigenetics Druggable Targets for Anti-cancer Therapies

Datta, Kaushik, Kolaja, Kyle

Journal:

Current Opinion in Toxicology

Year:

2017

Language:

english

File:

PDF, 854 KB

english, 2017

47

The human iPSC-cardiomyocyte arrhythmic risk (hCAR) assessment model to improve drug cardiac safety evaluation

Guo, Liang, Coyle, Luke, Abrams, Rory, Heidelberger, Cheryl, Singer, Thomas, Weiser, Thomas, Chiao, Eric, Kemper, Ray, Kolaja, Kyle

Journal:

Journal of Pharmacological and Toxicological Methods

Year:

2013

Language:

english

File:

PDF, 63 KB

english, 2013

48

Subchronic Effects of Dieldrin and Phenobarbital on Hepatic DNA Synthesis in Mice and Rats

KOLAJA, KYLE L., STEVENSON, DONALD E., JOHNSON, JASON T., WALBORG, EARL F., KLAUNIG, JAMES E.

Journal:

Toxicological Sciences

Year:

1996

Language:

english

File:

PDF, 6.06 MB

english, 1996

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